Biopsy for hepatocellular carcinoma: only occasionally

Hepatocellular Carcinoma in Sheep

Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma

Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...

Unusual presentation; seeding of tumor after biopsy for hepatocellular carcinoma

Hepatocellular cancer is one of the most common and fatal cancer tumor worldwide. However, the obtained results are questionable in terms of medical treatment of hepatocellular cancer. The muscle, soft tissue and cutaneous metastases of hepatocellular cancer, for instance, are rare and may result from interventional procedures. Seeding of tumor along the biopsy needle upon percutaneous biopsy i...

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

Surveillance of hepatocellular carcinoma: is only ultrasound enough?

Early detection of hepatocellular carcinoma (HCC) is very important because the 5-year survival rate of early stage HCC (about 40% to 70%) is better than that of advanced stage HCC (less than 5%). In some countries, high-risk patients undergo a hepatocarcinoma surveillance program using ultrasound and serum alphafetoprotein (AFP) levels. However, there are several drawbacks of surveillance prog...